Experience in the use of natural vitamin E (Enat 400) for the treatment of diffuse dyshormonal mastopathy.

Experience in the use of natural vitamin E (Enat 400) for the treatment of diffuse dyshormonal mastopathy.

Fibrocystic breast disease (FCM)

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The main role in the occurrence of FCM is attributed to dyshormonal disorders in the woman’s body. An important role in the pathogenesis of FCM belongs to relative or absolute hyperestrogenism and progesterone deficiency state. Estrogens cause the proliferation of the ductal alveolar epithelium and stroma, and progesterone counteracts these processes, ensures the differentiation of the epithelium and the cessation of mitotic activity.

Progesterone has the ability to reduce the expression of estrogen receptors, as well as the local level of active estrogens, thereby limiting the stimulation of breast tissue proliferation.

The shift in the balance of hormones in the tissues of the breast towards progesterone deficiency is accompanied by edema and hypertrophy of the intralobular connective tissue, and the proliferation of the ductal epithelium leads to the formation of cysts.

In the development of FCM, an important role is played by the level of blood prolactin, which has a diverse effect on the tissue of the mammary glands, stimulating metabolic processes in their epithelium throughout a woman’s life. Hyperprolactinemia outside of pregnancy is accompanied by swelling, engorgement, tenderness and edema of the mammary glands, more pronounced in the second phase of the menstrual cycle.

Thyroid hormones are important in the morphogenesis and functional differentiation of mammary epithelial cells. The action of thyroid hormones on the mammary gland can be realized in various ways.

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In the formation of dyshormonal pathology of the mammary glands, an indirect role is played by liver diseases, which, as a rule, are the cause of chronic hyperestrogenemia.

The algorithm for treating diffuse mastopathy includes both compliance with recommendations regarding lifestyle, nutrition, sexual behavior and rational contraception, selection of a bra, and medical correction. In the treatment of mastopathy, phytopreparations are widely used that normalize the hormonal background, hormonal preparations, multivitamins.

Vitamin E is widely used in the treatment of mastopathy. Natural vitamin E (d-alpha-tocopherol) is a natural form of vitamin E, a fat-soluble vitamin with powerful antioxidant properties. D-alpha-tocopherol is considered necessary for the stabilization of biological membranes (especially with a large amount of polyunsaturated fatty acids), it is a potent peroxyl radical acceptor and non-competitively inhibits cyclooxygenase activity in many tissues, which leads to a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor growth by inhibiting transcription of the vascular endothelial growth factor (VEGF) gene. Vitamin E has an immunomodulatory, antioxidant effect, enhances the production of endogenous progesterone.

E.N. Boris et al., Referring to the totality of literary sources, argue that vitamin E

prevents the formation of toxic biochemical products in the blood during the process of peroxidation; helps to reduce the activity of oxidative stress; stabilizes the cell membrane; protects cellular structures from destruction by free radicals; regulates protein synthesis and cell proliferation; https://jiji-ethiopia.com/lideta/car-parts-and-accessories/water-pump-for-toyota-hiace-2kd-and-hilux-d4d-n3e76HSdEGh9levhu4hn0nJq.html participates in the biosynthesis of heme; improves the processes of tissue respiration; activates the synthesis of protein, immunoglobulins and nonspecific defense factors.

Vitamin E

There is also a synthetic form of vitamin E

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